What is PEP?

PEP, or Post-Exposure Prophylaxis, is a preventive medication treatment aimed at reducing the acquisition of a virus or bacteria, especially where there is a known or suspected exposure to a virus or bacteria such as HIV (Human Immunodeficiency Virus), HBV (Hepatitis B), or other STIs (Sexually Transmitted Infections).

“PEP was first used in the late 1980s for occupational HIV exposures. The CDC released its first guidelines for PEP in 1990.”

How does PEP generally work?

  1. Timing: PEP needs to be initiated as soon as possible after exposure, ideally within hours, and certainly within 72 hours (3 days), depending on the specific virus or bacteria.

  2. Duration: The duration of PEP treatment varies depending on the specific virus or bacteria and protocol recommended by health authorities. For example, HIV PEP typically involves taking antiretroviral medications for 28 days. All PEP treatments should be completed fully for best results.

  3. Effectiveness: PEP is not 100% effective but significantly reduces the acquisition of a virus or bacteria when taken correctly and promptly after exposure.

How can I get PEP?

If you think you have been exposed to a specific virus or bacteria, such as HIV, schedule an appointment as soon as possible to talk to a provider. If you are unable to see your provider, you should go to an emergency room for immediate testing and treatment. Patients should not wait more than 72 hours (3 days) after exposure to start a PEP treatment.